Reaction Details Report a problem with these data
Target
Acetylcholinesterase
Ligand
BDBM476179
Substrate
n/a
Meas. Tech.
AChE inhibition
EC50
100.0±n/a nM
Citation
 Becker, RE Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions US Patent  US10864192 Publication Date 12/15/2020 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM476179
Synonyms:
(−)-N1, N8-bisnorphenylcarbamoyleseroline | US10864192, Compound N-1, N-8 BisNor P
Type:
Small organic molecule
Emp. Form.:
C18H19N3O2
Mol. Mass.:
309.3624
SMILES:
C[C@@]12CCN[C@@H]1Nc1ccc(OC(=O)Nc3ccccc3)cc21 |r|
Structure:
Search PDB for entries with ligand similarity: