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Target
Cytochrome P450 26B1
Ligand
BDBM476229
Substrate
n/a
Meas. Tech.
Cell-Based Inhibitor Assay
IC50
>1000000±n/a nM
Citation
 Cameron, DA; Petkovich, M; Rantanen, TK; Snieckus, V; Board, J; Singh, S; Maheta, AJ Compounds and methods for inhibiting CYP26 enzymes US Patent  US10874634 Publication Date 12/29/2020 
Target
Name:
Cytochrome P450 26B1
Synonyms:
CP26B_HUMAN | CYP26A2 | CYP26A2 | CYP26B1 | Cytochrome P450 26A2 | Cytochrome P450 26B1 | Cytochrome P450 retinoic acid-inactivating 2 | Cytochrome P450RAI-2 | P450RAI2 | Retinoic acid-metabolizing cytochrome
Type:
PROTEIN
Mol. Mass.:
57525.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115648
Residue:
512
Sequence:
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
  
Inhibitor
Name:
BDBM476229
Synonyms:
US10874634, Cmpd No. 11
Type:
Small organic molecule
Emp. Form.:
C25H35NO4S
Mol. Mass.:
445.615
SMILES:
CC(C)c1cc(c(cc1S(=O)(=O)Nc1ccc(CC(O)=O)cc1)C(C)(C)C)C(C)(C)C
Structure:
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