Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase Chk2
Ligand
BDBM50526803
Substrate
n/a
Meas. Tech.
Inhibition of Kinase Activity
IC50
<100.0±n/a nM
Citation
 Gray, NS; Liang, Y; Zhang, T; Kwiatkowski, NP Inhibitors of cyclin-dependent kinase 7 (CDK7) US Patent  US10870651 Publication Date 12/22/2020 
Target
Name:
Serine/threonine-protein kinase Chk2
Synonyms:
CHK2_HUMAN | CHEK2 | CDS1 | CHK2 | RAD53 | Serine/threonine-protein kinase Chk1/2 | Checkpoint Kinase (Chk2) | Serine/threonine-protein kinase Chek2
Type:
Protein
Mol. Mass.:
60908.59
Organism:
Human
Description:
O96017
Residue:
543
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
  
Inhibitor
Name:
BDBM50526803
Synonyms:
CHEMBL4434871 | US10870651, Compound 101
Type:
Small organic molecule
Emp. Form.:
C34H38N8O3
Mol. Mass.:
606.73
SMILES:
CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3cccc(NC(=O)c4ccc(NC(=O)C=C)cc4)c3)n[nH]c2C1(C)C)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: