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Target
D(3) dopamine receptor
Ligand
BDBM476769
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.110±n/a nM
Citation
 Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent  US10870660 Publication Date 12/22/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476769
Synonyms:
US10870660, Compound III-102 | US11345716, Compound III-102
Type:
Small organic molecule
Emp. Form.:
C25H33F4N5O2
Mol. Mass.:
511.5554
SMILES:
Cn1cc(CC(=O)N[C@H]2CC[C@](F)(CCN3CCc4ccc(OCC(F)(F)F)nc4CC3)CC2)cn1 |r,wU:11.12,wD:8.7,11.11,(13.46,1.84,;11.92,1.84,;11.01,3.09,;9.55,2.61,;8.22,3.38,;6.88,2.61,;6.88,1.07,;5.55,3.38,;4.22,2.61,;2.88,3.38,;1.55,2.61,;1.55,1.07,;1.55,-.47,;.21,.3,;-1.12,1.07,;-2.45,.3,;-2.34,-1.23,;-3.47,-2.28,;-4.99,-2.05,;-5.76,-3.38,;-7.3,-3.38,;-8.07,-2.05,;-9.61,-2.05,;-10.38,-.72,;-11.92,-.72,;-12.69,.62,;-12.69,-2.05,;-13.46,-.72,;-7.3,-.72,;-5.76,-.72,;-5.2,.72,;-3.73,1.17,;2.88,.3,;4.22,1.07,;9.55,1.07,;11.01,.6,)|
Structure:
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