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Target
D(3) dopamine receptor
Ligand
BDBM476808
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.250±n/a nM
Citation
 Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent  US10870660 Publication Date 12/22/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476808
Synonyms:
US10870660, Compound III-264 | US11345716, Compound III-264
Type:
Small organic molecule
Emp. Form.:
C22H29F4N5O3S
Mol. Mass.:
519.556
SMILES:
Cc1nc(CC(=O)N[C@H]2CC[C@](F)(CCN3CCc4nc(OCC(F)(F)F)sc4CC3)CC2)no1 |r,wU:11.12,wD:8.7,11.11,(13.11,2.59,;11.57,2.59,;10.67,3.84,;9.2,3.36,;7.87,4.13,;6.53,3.36,;6.53,1.82,;5.2,4.13,;3.87,3.36,;2.53,4.13,;1.2,3.36,;1.2,1.82,;1.2,.28,;-.13,1.05,;-1.47,1.82,;-2.8,1.05,;-4.07,1.92,;-5.55,1.46,;-6.11,.03,;-7.62,-.29,;-7.78,-1.82,;-9.11,-2.59,;-10.44,-1.82,;-11.78,-2.59,;-11.78,-4.13,;-13.11,-1.82,;-13.11,-3.36,;-6.37,-2.45,;-5.34,-1.3,;-3.82,-1.53,;-2.69,-.48,;2.53,1.05,;3.87,1.82,;9.2,1.82,;10.67,1.34,)|
Structure:
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