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Target
D(3) dopamine receptor
Ligand
BDBM476862
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.120±n/a nM
Citation
 Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent  US10870660 Publication Date 12/22/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476862
Synonyms:
US10870660, Compound II-029 | US11345716, Compound II-029
Type:
Small organic molecule
Emp. Form.:
C24H34F2N4O3S
Mol. Mass.:
496.614
SMILES:
Cc1ncc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OCC(C)(F)F)sc4CC3)CC2)o1 |r,wU:12.12,wD:9.8,(13.21,2.3,;11.67,2.3,;10.77,1.05,;9.3,1.53,;9.3,3.07,;7.97,3.84,;6.63,3.07,;6.63,1.53,;5.3,3.84,;3.97,3.07,;2.63,3.84,;1.3,3.07,;1.3,1.53,;-.03,.76,;-1.37,1.53,;-2.7,.76,;-3.91,1.72,;-5.41,1.38,;-6.08,-.01,;-7.6,-.22,;-7.88,-1.73,;-9.21,-2.5,;-10.54,-1.73,;-11.88,-2.5,;-13.21,-1.73,;-12.65,-3.84,;-11.11,-3.84,;-6.52,-2.46,;-5.41,-1.4,;-3.91,-1.74,;-2.7,-.78,;2.63,.76,;3.97,1.53,;10.77,3.54,)|
Structure:
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