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Target
D(3) dopamine receptor
Ligand
BDBM476870
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.096±n/a nM
Citation
 Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent  US10870660 Publication Date 12/22/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476870
Synonyms:
US10870660, Compound II-085 | US11345716, Compound II-085
Type:
Small organic molecule
Emp. Form.:
C23H31F3N4O3S
Mol. Mass.:
500.577
SMILES:
Cc1ncc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OCC(F)(F)F)sc4CC3)CC2)o1 |r,wU:12.12,wD:9.8,(13.24,2.65,;11.7,2.65,;10.93,1.32,;9.43,1.64,;9.27,3.17,;7.93,3.94,;6.6,3.17,;6.6,1.63,;5.27,3.94,;3.93,3.17,;2.6,3.94,;1.27,3.17,;1.27,1.63,;-.07,.86,;-1.4,1.63,;-2.74,.86,;-3.94,1.82,;-5.44,1.48,;-6.11,.09,;-7.64,-.12,;-7.91,-1.63,;-9.24,-2.4,;-10.58,-1.63,;-11.91,-2.4,;-13.24,-3.17,;-13.24,-1.63,;-11.91,-3.94,;-6.55,-2.36,;-5.44,-1.3,;-3.94,-1.64,;-2.74,-.68,;2.6,.86,;3.93,1.63,;10.67,3.8,)|
Structure:
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