Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM476887
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.120±n/a nM
Citation
 Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent  US10870660 Publication Date 12/22/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476887
Synonyms:
US10870660, Compound I-098
Type:
Small organic molecule
Emp. Form.:
C24H32F2N4O2S
Mol. Mass.:
478.598
SMILES:
Cc1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4sc(nc4C3)C3CC(F)(F)C3)CC2)on1 |r,wU:8.7,wD:11.11,(13.03,1.57,;11.5,1.41,;10.47,2.55,;9.06,1.93,;7.73,2.69,;6.39,1.93,;6.39,.38,;5.06,2.69,;3.73,1.93,;3.73,.38,;2.39,-.38,;1.06,.38,;-.27,-.38,;-1.61,.38,;-2.94,-.38,;-2.94,-1.93,;-4.28,-2.69,;-5.61,-1.93,;-7.07,-2.4,;-7.98,-1.15,;-7.07,.09,;-5.61,-.38,;-4.28,.38,;-9.52,-1.15,;-10.61,-.07,;-11.7,-1.15,;-13.03,-.38,;-13.03,-1.93,;-10.61,-2.24,;1.06,1.93,;2.39,2.69,;9.22,.39,;10.73,.07,)|
Structure:
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