Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2 [23-117]
Ligand
BDBM454369
Substrate
n/a
Meas. Tech.
Inhibition AlphaScreen Assay
IC50
2.00±n/a nM
Citation
 Gollner, A; Broeker, J; Kerres, N; Kofink, C; Ramharter, J; Weinstabl, H; Gille, A; Goepper, S; Henry, M; Huchler, G Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors US Patent  US10882866 Publication Date 1/5/2021 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [23-117]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 (23-117) | MDM2 | MDM2 (aa 23-117) | MDM2_HUMAN
Type:
Oncoprotein
Mol. Mass.:
11177.88
Organism:
Homo sapiens (Human)
Description:
Q00987[23-117]
Residue:
95
Sequence:
EQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSD
  
Inhibitor
Name:
BDBM454369
Synonyms:
US10717742, Example Ia-25 | US10882866, Example Ia-25
Type:
Small organic molecule
Emp. Form.:
C30H23Cl2FN4O3
Mol. Mass.:
577.433
SMILES:
OC(=O)c1ccc2c3C[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r|
Structure:
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