Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM477626
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
IC50
5700±n/a nM
Citation
 Li, X; He, W; Wang, B; Zhang, Z; He, F; Tao, W Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine US Patent  US10889569 Publication Date 1/12/2021 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM477626
Synonyms:
3-Chloro-1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl)azetidin-3-yl)-5-fluoro-1H-indole 4 | US10889569, Example 10 | US10889569, Example 4
Type:
Small organic molecule
Emp. Form.:
C21H20ClFN6O2
Mol. Mass.:
442.874
SMILES:
COCc1nnc(N2CC(C2)n2cc(Cl)c3cc(F)ccc23)n1-c1ccc(OC)nc1
Structure:
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