Target
Serine/threonine-protein kinase TBK1
Ligand
BDBM478581
Substrate
n/a
Meas. Tech.
TBK1 Low ATP Kinase Assay
IC50
0.640±n/a nM
Citation
 Schulze, VHeinrich, TPrinz, FLefranc, JSchröder, JMengel, ABone, WBálint, JWengner, AMEis, KIrlbacher, HKoppitz, MBömer, UBader, BBriem, HLienau, PChrist, CStöckigt, DHillig, R Heteroarylbenzimidazole compounds US Patent  US10894784 Publication Date 1/19/2021 
Target
Name:
Serine/threonine-protein kinase TBK1
Synonyms:
NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN
Type:
protein
Mol. Mass.:
83645.20
Organism:
Homo sapiens (Human)
Description:
Q9UHD2
Residue:
729
Sequence:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
  
Inhibitor
Name:
BDBM478581
Synonyms:
1-{4-[(1R or 1S)-1-{2-[(6-{1-[(1-chlorocyclopropyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one | US10894784, Example 69.02
Type:
Small organic molecule
Emp. Form.:
C28H30ClF3N8O
Mol. Mass.:
587.039
SMILES:
CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3(Cl)CC3)c2)c1
Structure:
Search PDB for entries with ligand similarity: