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Target
Menin
Ligand
BDBM480318
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Competitive Binding Assay
IC50
798±n/a nM
Citation
 Wang, S; Aguilar, A; Zheng, K; Xu, S; Xu, T; Bernard, D; Huang, L Piperidines as menin inhibitors US Patent  US10899738 Publication Date 1/26/2021 
Target
Name:
Menin
Synonyms:
MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2
Type:
Protein
Mol. Mass.:
68022.55
Organism:
Homo sapiens (Human)
Description:
O00255
Residue:
610
Sequence:
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL
  
Inhibitor
Name:
BDBM480318
Synonyms:
US10899738, Cpd. No 380 | rac-(1S,2R)-2-(1-(1-(4-(4- cyanophenyl)butanoyl) piperidin-4-yl)-2- (1H-imidazol-1- yl)-1- phenylethyl)cyclopentyl methylcarbamate
Type:
Small organic molecule
Emp. Form.:
C34H41N5O3
Mol. Mass.:
567.721
SMILES:
CNC(=O)O[C@H]1CCC[C@@H]1C(Cn1ccnc1)(C1CCN(CC1)C(=O)CCCc1ccc(cc1)C#N)c1ccccc1 |r|
Structure:
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