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Target
Apelin receptor
Ligand
BDBM481004
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
0.220±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481004
Synonyms:
US10906890, Example 13.0
Type:
Small organic molecule
Emp. Form.:
C27H32N6O5S
Mol. Mass.:
552.645
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1ccccc1 |r,wU:16.17,wD:18.19,(-6.57,1.79,;-5.24,1.02,;-3.9,1.79,;-3.9,3.33,;-2.57,4.1,;-1.23,3.33,;-1.23,1.79,;.1,1.02,;1.43,1.79,;-2.57,1.02,;-2.57,-.52,;-1.32,-1.42,;.01,-.65,;1.34,-1.42,;.26,-2.51,;2.68,-2.19,;2.43,-.33,;2.04,1.16,;3.92,-.73,;4.32,-2.22,;5.81,-2.62,;6.9,-1.53,;6.21,-4.1,;5.01,.36,;6.5,-.04,;7.59,1.05,;7.19,2.54,;8.28,3.63,;5.7,2.93,;4.61,1.85,;-1.8,-2.89,;-3.34,-2.89,;-3.81,-1.42,;-5.3,-1.02,;-5.7,.47,;-7.19,.86,;-8.28,-.23,;-7.88,-1.71,;-6.39,-2.11,)|
Structure:
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