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Target
Apelin receptor
Ligand
BDBM481014
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
0.270±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481014
Synonyms:
US10906890, Example 23.0 | US10906890, Example 24.0
Type:
Small organic molecule
Emp. Form.:
C24H27N7O5S
Mol. Mass.:
525.58
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccccc2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(3.4,-3.93,;4.43,-2.79,;3.95,-1.32,;2.45,-1,;1.97,.46,;1.42,-2.15,;2.56,-3.18,;.39,-3.29,;.27,-1.12,;-1.19,-1.59,;-1.67,-3.06,;-3.21,-3.06,;-3.68,-1.59,;-5.15,-1.12,;-5.47,.39,;-6.93,.87,;-8.08,-.17,;-7.76,-1.67,;-6.29,-2.15,;-2.44,-.69,;-2.44,.85,;-1.1,1.62,;.23,.85,;1.56,1.62,;-1.1,3.16,;-2.44,3.93,;-3.77,3.16,;-3.77,1.62,;-5.1,.85,;-6.44,1.62,;4.99,-.18,;6.49,-.5,;7.52,.65,;7.05,2.11,;8.08,3.25,;5.54,2.43,;4.51,1.29,)|
Structure:
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