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Target
Apelin receptor
Ligand
BDBM481021
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
100.0±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481021
Synonyms:
US10906890, Example 30.0
Type:
Small organic molecule
Emp. Form.:
C24H27N9O4S
Mol. Mass.:
537.594
SMILES:
COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H]2CCCN(C2)c2ncc(C)cn2)nnc1-c1ccccc1 |r,wD:16.16,(-7.92,-7.86,;-6.58,-8.63,;-5.25,-7.86,;-5.25,-6.32,;-3.92,-5.55,;-2.58,-6.32,;-2.58,-7.86,;-1.25,-8.63,;.09,-7.86,;-3.92,-8.63,;-3.92,-10.17,;-2.67,-11.08,;-1.2,-10.6,;-.06,-11.63,;-1.15,-12.72,;1.03,-12.72,;1.03,-10.54,;.63,-9.06,;1.72,-7.97,;3.21,-8.36,;3.61,-9.85,;2.52,-10.94,;5.09,-10.25,;5.49,-11.74,;6.98,-12.14,;8.07,-11.05,;9.56,-11.45,;7.67,-9.56,;6.18,-9.16,;-3.15,-12.54,;-4.69,-12.54,;-5.16,-11.08,;-6.63,-10.6,;-6.95,-9.09,;-8.41,-8.62,;-9.56,-9.65,;-9.23,-11.16,;-7.77,-11.63,)|
Structure:
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