Reaction Details Report a problem with these data
Target
Programmed cell death protein 1
Ligand
BDBM482539
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay ELISA
IC50
<5±n/a nM
Citation
 Lange, C; Malathong, V; Mali, VR; McMahon, J; McMurtrie, DJ; Punna, S; Roth, HS; Singh, R; Wang, Y; Yang, J; Zhang, P Immunomodulator compounds US Patent  US10919852 Publication Date 2/16/2021 
Target
Name:
Programmed cell death protein 1
Synonyms:
CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1
Type:
PROTEIN
Mol. Mass.:
31650.07
Organism:
Homo sapiens
Description:
ChEMBL_108437
Residue:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
  
Inhibitor
Name:
BDBM482539
Synonyms:
US10919852, Compound TABLE 1.238 | US11708326, Compound TABLE 1.238
Type:
Small organic molecule
Emp. Form.:
C43H44Cl2FN5O4
Mol. Mass.:
784.745
SMILES:
FC1CC2(C1)CN(CCCOc1cccc(c1Cl)-c1cccc3[C@H](CCc13)Oc1cc(OCc3cncc(c3)C#N)c(CNC[C@H]3CCC(=O)N3)cc1Cl)C2 |r|
Structure:
Search PDB for entries with ligand similarity: