Reaction Details Report a problem with these data
Target
Programmed cell death protein 1
Ligand
BDBM482549
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay ELISA
IC50
<5±n/a nM
Citation
 Lange, C; Malathong, V; Mali, VR; McMahon, J; McMurtrie, DJ; Punna, S; Roth, HS; Singh, R; Wang, Y; Yang, J; Zhang, P Immunomodulator compounds US Patent  US10919852 Publication Date 2/16/2021 
Target
Name:
Programmed cell death protein 1
Synonyms:
CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1
Type:
PROTEIN
Mol. Mass.:
31650.07
Organism:
Homo sapiens
Description:
ChEMBL_108437
Residue:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
  
Inhibitor
Name:
BDBM482549
Synonyms:
US10919852, Compound TABLE 1.248 | US11708326, Compound TABLE 1.248
Type:
Small organic molecule
Emp. Form.:
C46H50ClN5O4
Mol. Mass.:
772.373
SMILES:
CC1CCN(CCCOc2cccc(c2C)-c2cccc3[C@H](CCc23)Oc2cc(OCc3cc(cc(c3)C#N)C#N)c(CNC[C@H]3CCC(=O)N3)cc2Cl)CC1 |r|
Structure:
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