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Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM223491
Substrate
n/a
Meas. Tech.
Alpha-assay
IC50
3.48±n/a nM
Citation
 Landau, SB; Kagey, MH Treatment of conditions associated with hyperinsulinaemia US Patent  US10925881 Publication Date 2/23/2021 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM223491
Synonyms:
US10407441, Compound JQ6 | US10925881, Name (S)-JQ6 | US9320741, JQ6
Type:
Small organic molecule
Emp. Form.:
C23H21ClN8OS
Mol. Mass.:
492.984
SMILES:
Cc1nnc2[C@H](CC(=O)N\N=C\c3ncc[nH]3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:18|
Structure:
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