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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM483621
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
40.0±n/a nM
Citation
 Liu, K; Clausen, D; Guo, L; Han, Y; He, S; Kozlowski, J; Li, D; Pu, Q; Yu, W; Zhang, H Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors US Patent  US10927086 Publication Date 2/23/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM483621
Synonyms:
N- [(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-yl]-N''-hydroxy-4-{[2-(S- methylsulfonimidoyl)-2- azaspiro[3.3]heptan-6-yl]amino}-1,2,5- oxadiazole-3-carboximidamide (isomer 1) | US10927086, Example 76 | US10927086, Example 77
Type:
Small organic molecule
Emp. Form.:
C18H22FN7O3S
Mol. Mass.:
435.476
SMILES:
CS(=N)(=O)N1CC2(CC(C2)Nc2nonc2\C(N[C@@H]2Cc3ccc(F)cc23)=N/O)C1 |r|
Structure:
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