Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM483765
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM483765
Synonyms:
1-((2R,4S)-2- methyl-4-(methyl(3- (trifluoromethyl)- benzyl)amino)- piperidine-1- carbonyl)-1H- pyrazole-3- carboxamide | US10927105, Ex 260 | US11655217, Example 260
Type:
Small organic molecule
Emp. Form.:
C20H24F3N5O2
Mol. Mass.:
423.4321
SMILES:
C[C@@H]1C[C@H](CCN1C(=O)n1ccc(n1)C(N)=O)N(C)Cc1cccc(c1)C(F)(F)F |r|
Structure:
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