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Target
SH2B adapter protein 2
Ligand
BDBM484424
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
44.0±n/a nM
Citation
 Chen, Z; Fortanet, JG; Karki, R; Lamarche, MJ; Majumdar, D; Perez, LB; Sendzik, M; Smith, TD; Yang, F; Yu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent  US10934285 Publication Date 3/2/2021 
Target
Name:
SH2B adapter protein 2
Synonyms:
APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN
Type:
Protein
Mol. Mass.:
67733.52
Organism:
Human
Description:
O14492
Residue:
632
Sequence:
MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEAAPGRARAVENQYSFY
  
Inhibitor
Name:
BDBM484424
Synonyms:
US10934285, Example 8
Type:
Small organic molecule
Emp. Form.:
C28H30ClN7O3S
Mol. Mass.:
580.101
SMILES:
Cn1c2ccccc2c(O)c(C(=O)Nc2cccc(Sc3ncc(nc3N)N3CCC(C)(CN)CC3)c2Cl)c1=O
Structure:
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