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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM340106
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
EC50
>1000±n/a nM
Citation
Barf, TA; Jans, CG; de Man, AP; Oubrie, AA; Raaijmakers, HC; Rewinkel, JB; Sterrenburg, JG; Wijkmans, JC 4-imidazopyridazin-1-yl-benzamides as Btk inhibitors US Patent US10934296 Publication Date 3/2/2021
More Info.:
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Inhibitor
Name:
BDBM340106
Synonyms:
(E)-4-(8-amino-3-((4-methoxybut-2- enamido)methyl)imidazo[1,5- a]pyrazin-1-yl)-N-(pyridin-2- yl)benzamide | US10239883, Example 95 | US10934296, Example 95 | US9758524, Example 95
Type:
Small organic molecule
Emp. Form.:
C24H23N7O3
Mol. Mass.:
457.4845
SMILES:
COC\C=C\C(=O)NCc1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12