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Target
Mitogen-activated protein kinase 1
Ligand
BDBM485127
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<50±n/a nM
Citation
 Huang, PQ; Kahraman, M; Bunker, KD Spirocyclic compounds US Patent  US10934304 Publication Date 3/2/2021 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM485127
Synonyms:
US10934304, Example 48
Type:
Small organic molecule
Emp. Form.:
C35H46N10O3
Mol. Mass.:
654.8049
SMILES:
CN\C=N/C(=N)c1ccc(cc1)C1=CCN(CC1)C(=O)CN1CC[C@]2(CCN(C2=O)c2ccc(N)c(n2)C(=N)N2C[C@H](C)O[C@H](C)C2)C1 |r,t:13|
Structure:
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