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Target
Serine hydroxymethyltransferase, cytosolic
Ligand
BDBM285658
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
0.170±n/a nM
Citation
 Rabinowitz, JD; Kim, H; Ducker, GS; Ghergurovich, JM SHMT inhibitors US Patent  US10934305 Publication Date 3/2/2021 
Target
Name:
Serine hydroxymethyltransferase, cytosolic
Synonyms:
GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase
Type:
PROTEIN
Mol. Mass.:
53091.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_745716
Residue:
483
Sequence:
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
  
Inhibitor
Name:
BDBM285658
Synonyms:
US10077273, Compound 4 | US10584132, Compound 4 | US10934305, Compound 4
Type:
Small organic molecule
Emp. Form.:
C23H21F3N4O3
Mol. Mass.:
458.433
SMILES:
CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(O)=O |c:13|
Structure:
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