Reaction Details Report a problem with these data
Target
Fascin
Ligand
BDBM350102
Substrate
n/a
Meas. Tech.
High Throughput Inhibition Assay
IC50
652±n/a nM
Citation
 Huang, X; Shue, CY Methods for inhibiting fascin US Patent  US10941146 Publication Date 3/9/2021 
Target
Name:
Fascin
Synonyms:
55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54533.89
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
493
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
  
Inhibitor
Name:
BDBM350102
Synonyms:
2-chloro-N-(6- chlorobenzo[d]thiazol-2- yl)-5- nitrobenzenesulfonamide | US10208043, # 3 | US10941146, # 3
Type:
Small organic molecule
Emp. Form.:
C13H7Cl2N3O4S2
Mol. Mass.:
404.248
SMILES:
[O-][N+](=O)c1ccc(Cl)c(c1)S(=O)(=O)Nc1nc2ccc(Cl)cc2s1
Structure:
Search PDB for entries with ligand similarity: