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Target
Fascin
Ligand
BDBM350121
Substrate
n/a
Meas. Tech.
High Throughput Inhibition Assay
IC50
3400±n/a nM
Citation
 Huang, X; Shue, CY Methods for inhibiting fascin US Patent  US10941146 Publication Date 3/9/2021 
Target
Name:
Fascin
Synonyms:
55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54533.89
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
493
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
  
Inhibitor
Name:
BDBM350121
Synonyms:
2-(4-oxo-1-(S,S,-dioxo- tetrahydrothiophen-3-yl)- 1H-pyrazolo[3,4-d] pyrimidin-5(4H)-yl)-N- (3-(trifluoromethyl) phenyl)acetamide | US10208043, # 23 | US10941146, # 23
Type:
Small organic molecule
Emp. Form.:
C18H16F3N5O4S
Mol. Mass.:
455.411
SMILES:
FC(F)(F)c1cccc(NC(=O)Cn2cnc3n(ncc3c2=O)C2CCS(=O)(=O)C2)c1
Structure:
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