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Target
Fascin
Ligand
BDBM350127
Substrate
n/a
Meas. Tech.
High Throughput Inhibition Assay
IC50
3700±n/a nM
Citation
 Huang, X; Shue, CY Methods for inhibiting fascin US Patent  US10941146 Publication Date 3/9/2021 
Target
Name:
Fascin
Synonyms:
55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54533.89
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
493
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
  
Inhibitor
Name:
BDBM350127
Synonyms:
5-(2-(benzo[d][1,3]dioxol- 5-yl)-2-oxoethyl)-1-(S,S- dioxo-tetrahydrothiophen- 3-yl)-1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one | US10208043, # 29 | US10941146, # 29
Type:
Small organic molecule
Emp. Form.:
C18H16N4O6S
Mol. Mass.:
416.408
SMILES:
O=C(Cn1cnc2n(ncc2c1=O)C1CCS(=O)(=O)C1)c1ccc2OCOc2c1
Structure:
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