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Target
Fascin
Ligand
BDBM350130
Substrate
n/a
Meas. Tech.
High Throughput Inhibition Assay
IC50
2100±n/a nM
Citation
 Huang, X; Shue, CY Methods for inhibiting fascin US Patent  US10941146 Publication Date 3/9/2021 
Target
Name:
Fascin
Synonyms:
55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54533.89
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
493
Sequence:
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
  
Inhibitor
Name:
BDBM350130
Synonyms:
5-(3,4-dichlorobenzyl)-1- (2,4-dimethylphenyl)-1H- pyrazolo[3,4-d]pyrimidin- 4(5H)-one | US10208043, # 32 | US10941146, # 32
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2N4O
Mol. Mass.:
399.273
SMILES:
Cc1ccc(c(C)c1)-n1ncc2c1ncn(Cc1ccc(Cl)c(Cl)c1)c2=O
Structure:
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