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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM485871
Substrate
n/a
Meas. Tech.
in vitro transactivation assay
EC50
10000±n/a nM
Citation
 Vassilatis, DK; Spathis, AD; Fokas, D Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease US Patent  US10946019 Publication Date 3/16/2021 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM485871
Synonyms:
US10946019, Example 19
Type:
Small organic molecule
Emp. Form.:
C21H15ClF3N3O2
Mol. Mass.:
433.811
SMILES:
OC(=O)c1ccc(Nc2nc(nc(c2CC=C)C(F)(F)F)-c2ccc(Cl)cc2)cc1
Structure:
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