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Target
Tyrosine-protein kinase SYK [342-635]
Ligand
BDBM140377
Substrate
n/a
Meas. Tech.
GSK 3beta Kinase-Test
IC50
13.0±n/a nM
Citation
 Dahmann, G; Hoffmann, M; Klicic Badoux, J; Lamb, DJ; McCarthy, C; Napier, SC; Parrish, K; Scott, J; Fitzgerald, JL; Walker, E Heteroaryl SYK inhibitors US Patent  US10947243 Publication Date 3/16/2021 
Target
Name:
Tyrosine-protein kinase SYK [342-635]
Synonyms:
KSYK_HUMAN | SYK | SYK (aa 342-635)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34105.36
Organism:
Homo sapiens (Human)
Description:
P43405[342-635]
Residue:
294
Sequence:
PMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM140377
Synonyms:
US10947243, Example 102 | US8912173, 102 | US9914735, Example 102
Type:
Small organic molecule
Emp. Form.:
C23H21F3N2O3
Mol. Mass.:
430.4196
SMILES:
COc1cc(ccc1C(F)(F)F)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Structure:
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