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Target
Mitogen-activated protein kinase kinase kinase 12
Ligand
BDBM301557
Substrate
n/a
Meas. Tech.
DLK TR-FRET Inhibition Assay
Ki
41.8±n/a nM
Citation
 Estrada, A; Patel, S; Kellar, T; Huestis, M; Shore, D; Siu, M Tricyclic DLK inhibitors and uses thereof US Patent  US10131675 Publication Date 11/20/2018 
Target
Name:
Mitogen-activated protein kinase kinase kinase 12
Synonyms:
DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK
Type:
PROTEIN
Mol. Mass.:
93216.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1460553
Residue:
859
Sequence:
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
  
Inhibitor
Name:
BDBM301557
Synonyms:
US10131675, Example 43
Type:
Small organic molecule
Emp. Form.:
C21H23F2N7O2
Mol. Mass.:
443.4498
SMILES:
CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(OC(F)F)c1)N1CC2CC1C2 |(6.82,3.01,;5.33,2.61,;6.1,1.27,;5.17,4.14,;3.77,4.77,;2.52,3.86,;2.68,2.33,;4.09,1.7,;3.93,.17,;2.42,-.15,;1.65,-1.48,;.11,-1.48,;-.66,-.15,;.11,1.18,;1.65,1.18,;-2.2,-.15,;-2.97,-1.48,;-4.51,-1.48,;-5.28,-.15,;-6.82,-.15,;-4.51,1.18,;-5.28,2.52,;-4.51,3.85,;-5.28,5.19,;-2.97,3.85,;-2.97,1.18,;2.42,-2.82,;3.96,-2.82,;4.44,-4.28,;3.19,-5.19,;1.94,-4.28,;3.16,-3.55,)|
Structure:
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