Reaction Details Report a problem with these data
Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM487969
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
7.00±n/a nM
Citation
 Lu, T; Allison, BD; Barbay, JK; Connolly, PJ; Cummings, MD; Diels, G; Edwards, JP; Kreutter, KD; Philippar, U; Shen, F; Thuring, JW; Wu, T; Berthelot, DJ Pyrazole derivatives as MALT1 inhibitors US Patent  US10954214 Publication Date 3/23/2021 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM487969
Synonyms:
4-(4-((5-chloro-6-(2H-1,2,3- triazol-2-yl)pyridin-3- yl)carbamoyl)-5- (trifluoromethyl)-1H-pyrazol-1- yl)thieno[2,3-c]pyridine-7- carboxamide | US10954214, Compound 391
Type:
Small organic molecule
Emp. Form.:
C20H11ClF3N9O2S
Mol. Mass.:
533.874
SMILES:
NC(=O)c1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccsc12
Structure:
Search PDB for entries with ligand similarity: