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Target
Tyrosine-protein kinase JAK2 [831-1132]
Ligand
BDBM488661
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
1580±n/a nM
Citation
 Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG JAK1 selective inhibitors US Patent  US10961228 Publication Date 3/30/2021 
Target
Name:
Tyrosine-protein kinase JAK2 [831-1132]
Synonyms:
JAK2 | JAK2 (aa 831-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 831-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35337.99
Organism:
Homo sapiens (Human)
Description:
O60674[831-1132]
Residue:
302
Sequence:
GFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM488661
Synonyms:
(R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4-(2- hydroxyethyl)piperazin- 1-yl)propanamide | US10961228, Example 1
Type:
Small organic molecule
Emp. Form.:
C29H34FN7O4S
Mol. Mass.:
595.688
SMILES:
C[C@@H](N1CCN(CCO)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C |r|
Structure:
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