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Target
Tyrosine-protein kinase JAK2 [831-1132]
Ligand
BDBM488761
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
1160±n/a nM
Citation
 Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG JAK1 selective inhibitors US Patent  US10961228 Publication Date 3/30/2021 
Target
Name:
Tyrosine-protein kinase JAK2 [831-1132]
Synonyms:
JAK2 | JAK2 (aa 831-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 831-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35337.99
Organism:
Homo sapiens (Human)
Description:
O60674[831-1132]
Residue:
302
Sequence:
GFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM488761
Synonyms:
(S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)butanamide | US10961228, Example 30
Type:
Small organic molecule
Emp. Form.:
C29H33F2N7O3S
Mol. Mass.:
597.679
SMILES:
CC[C@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F |r|
Structure:
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