Reaction Details Report a problem with these data
Target
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Ligand
BDBM489223
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<10±n/a nM
Citation
 Osborne, S; Large, J Oxazole derivatives for use in the treatment of cancer US Patent  US10961233 Publication Date 3/30/2021 
Target
Name:
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Synonyms:
ADE2 | AIRC | Multifunctional protein ADE2 | PAICS | PAIS | PUR6_HUMAN
Type:
Protein
Mol. Mass.:
47081.21
Organism:
Human
Description:
P22234
Residue:
425
Sequence:
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL
  
Inhibitor
Name:
BDBM489223
Synonyms:
US10961233, Example 84
Type:
Small organic molecule
Emp. Form.:
C19H25BrN6O4S
Mol. Mass.:
513.409
SMILES:
Nc1nc(co1)C(=O)Nc1c(Br)cccc1N1CCN(CC1)S(=O)(=O)C1CCNCC1
Structure:
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