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Target
Histone-lysine N-methyltransferase EZH2
Ligand
BDBM490282
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay
IC50
<100±n/a nM
Citation
 Chen, X; Geng, M; Jiang, L; Chen, Y; Cao, J; Jiang, Q; Shen, Q; Ding, J; Yao, Y; Zhao, Z; Xiong, Y Pyrido five-element aromatic ring compound, preparation method therefor and use thereof US Patent  US10968215 Publication Date 4/6/2021 
Target
Name:
Histone-lysine N-methyltransferase EZH2
Synonyms:
ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6
Type:
Protein
Mol. Mass.:
85367.84
Organism:
Homo sapiens (Human)
Description:
Q15910
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM490282
Synonyms:
US10968215, Compound 159
Type:
Small organic molecule
Emp. Form.:
C31H37F3N6O4
Mol. Mass.:
614.6585
SMILES:
COc1cc(C)c(CNC(=O)c2cc3c(ccn3c([C@H](C)N3CCN(CC(F)(F)F)CC3)c2C)-c2c(C)noc2C)c(=O)[nH]1 |wU:19.20,(3.33,-9.14,;4.67,-8.37,;4.67,-6.83,;3.33,-6.06,;3.33,-4.52,;2,-3.75,;4.67,-3.75,;4.67,-2.21,;3.33,-1.44,;3.33,.1,;4.67,.87,;2,.87,;.67,.1,;-.67,.87,;-2.13,.4,;-3.04,1.64,;-2.13,2.89,;-.67,2.41,;.67,3.18,;.67,4.72,;2,5.49,;-.67,5.49,;-2,4.72,;-3.33,5.49,;-3.33,7.03,;-4.67,7.8,;-6,7.03,;-7.34,6.26,;-6.77,8.37,;-5.23,5.7,;-2,7.8,;-.67,7.03,;2,2.41,;3.33,3.18,;-2.61,-1.07,;-4.07,-1.54,;-5.32,-.64,;-4.07,-3.08,;-2.61,-3.56,;-1.7,-2.31,;-.16,-2.31,;6,-4.52,;7.34,-3.75,;6,-6.06,)|
Structure:
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