Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [181-417]
Ligand
BDBM373553
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
IC50
63.1±n/a nM
Citation
 Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H 4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors US Patent  US10975062 Publication Date 4/13/2021 
Target
Name:
Egl nine homolog 1 [181-417]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417)
Type:
Enzyme
Mol. Mass.:
26555.51
Organism:
Homo sapiens (Human)
Description:
aa 181-417
Residue:
237
Sequence:
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
  
Inhibitor
Name:
BDBM373553
Synonyms:
1-((4-Cyclopropanemethylamino)-6-(2,6-dimethylphenoxy)-7-fluoroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid; | US10246442, Example 15 | US10975062, Example 15
Type:
Small organic molecule
Emp. Form.:
C24H22FN5O3
Mol. Mass.:
447.4616
SMILES:
Cc1cccc(C)c1Oc1cc2c(NCC3CC3)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: