Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [181-417]
Ligand
BDBM373611
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
IC50
39.8±n/a nM
Citation
 Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H 4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors US Patent  US10975062 Publication Date 4/13/2021 
Target
Name:
Egl nine homolog 1 [181-417]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417)
Type:
Enzyme
Mol. Mass.:
26555.51
Organism:
Homo sapiens (Human)
Description:
aa 181-417
Residue:
237
Sequence:
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
  
Inhibitor
Name:
BDBM373611
Synonyms:
1-(6-(4-chlorophenoxy)-4-(4-cyanopiperidin-1-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid; | US10246442, Example 65 | US10975062, Example 65
Type:
Small organic molecule
Emp. Form.:
C24H19ClN6O3
Mol. Mass.:
474.899
SMILES:
OC(=O)c1cnn(c1)-c1nc(N2CCC(CC2)C#N)c2cc(Oc3ccc(Cl)cc3)ccc2n1
Structure:
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