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Target
Glutaminase kidney isoform, mitochondrial [63-669]
Ligand
BDBM492979
Substrate
n/a
Meas. Tech.
GLS Enzyme Potency Assay
IC50
23.5±n/a nM
Citation
 Nissink, JW; Finlay, MR; Charles, MD 1,3,4-thiadiazole compounds and their use in treating cancer US Patent  US10981904 Publication Date 4/20/2021 
Target
Name:
Glutaminase kidney isoform, mitochondrial [63-669]
Synonyms:
GLS | GLS1 | GLSK_HUMAN | Glutaminase kidney isoform, mitochondrial (aa 63-669) | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:
n/a
Mol. Mass.:
66963.68
Organism:
Homo sapiens (Human)
Description:
O94925 aa 63-669
Residue:
607
Sequence:
WPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
  
Inhibitor
Name:
BDBM492979
Synonyms:
2-(3,5-dimethoxyphenyl)-N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-methoxy-acetamide | US10981904, Example 26
Type:
Small organic molecule
Emp. Form.:
C21H24FN7O4S
Mol. Mass.:
489.523
SMILES:
CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cc(OC)cc(OC)c1 |r|
Structure:
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