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Target
Tyrosine-protein kinase JAK3 [512-1124]
Ligand
BDBM493075
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
37.7±n/a nM
Citation
 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent  US10981911 Publication Date 4/20/2021 
Target
Name:
Tyrosine-protein kinase JAK3 [512-1124]
Synonyms:
JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN
Type:
Protein
Mol. Mass.:
68951.94
Organism:
Homo sapiens (Human)
Description:
P52333[512-1124]
Residue:
613
Sequence:
TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM493075
Synonyms:
2-((1r,4r)-4-(2-(2H-1,2,3-Triazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 16
Type:
Small organic molecule
Emp. Form.:
C18H18N8
Mol. Mass.:
346.3891
SMILES:
N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1cn[nH]n1 |r,wU:3.2,wD:6.9,(5.65,3.67,;4.16,4.07,;2.67,4.47,;1.59,3.38,;1.98,1.9,;.9,.81,;-.59,1.2,;-.99,2.69,;.1,3.78,;-1.68,.12,;-3.21,.28,;-3.84,-1.12,;-2.7,-2.16,;-2.71,-3.7,;-1.38,-4.47,;-.04,-3.71,;1.42,-4.19,;2.33,-2.95,;1.43,-1.7,;-.04,-2.17,;-1.37,-1.39,;-3.98,1.62,;-5.49,1.94,;-5.65,3.47,;-4.24,4.1,;-3.21,2.95,)|
Structure:
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