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Target
Tyrosine-protein kinase JAK3 [512-1124]
Ligand
BDBM493169
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
32.9±n/a nM
Citation
 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent  US10981911 Publication Date 4/20/2021 
Target
Name:
Tyrosine-protein kinase JAK3 [512-1124]
Synonyms:
JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN
Type:
Protein
Mol. Mass.:
68951.94
Organism:
Homo sapiens (Human)
Description:
P52333[512-1124]
Residue:
613
Sequence:
TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM493169
Synonyms:
Diethyl 4-(2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamido)benzylphosphonate | US10981911, Example 108
Type:
Small organic molecule
Emp. Form.:
C29H35N6O4P
Mol. Mass.:
562.5998
SMILES:
CCOP(=O)(Cc1ccc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1)OCC |r,wU:29.32,wD:26.28,(-5.58,-1.17,;-6.35,.17,;-7.89,.17,;-8.66,1.5,;-10,2.27,;-7.89,2.83,;-6.35,2.83,;-5.58,4.17,;-4.04,4.17,;-3.27,2.83,;-1.73,2.83,;-.96,1.5,;-1.73,.17,;.58,1.5,;1.35,.17,;.72,-1.24,;1.87,-2.27,;1.87,-3.81,;3.2,-4.58,;4.53,-3.81,;6,-4.29,;6.9,-3.04,;6,-1.8,;4.53,-2.27,;3.2,-1.5,;2.88,0,;3.91,1.15,;5.42,.83,;6.45,1.97,;5.97,3.44,;7,4.58,;8.51,4.26,;10,3.86,;4.46,3.76,;3.43,2.61,;-4.04,1.5,;-5.58,1.5,;-9.75,.41,;-8.98,-.92,;-9.75,-2.26,)|
Structure:
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