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Target
Tyrosine-protein kinase JAK3 [512-1124]
Ligand
BDBM493279
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
13.7±n/a nM
Citation
 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent  US10981911 Publication Date 4/20/2021 
Target
Name:
Tyrosine-protein kinase JAK3 [512-1124]
Synonyms:
JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN
Type:
Protein
Mol. Mass.:
68951.94
Organism:
Homo sapiens (Human)
Description:
P52333[512-1124]
Residue:
613
Sequence:
TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM493279
Synonyms:
2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-cyanophenyl)acetamide | US10981911, Example 200
Type:
Small organic molecule
Emp. Form.:
C25H23N7O
Mol. Mass.:
437.4964
SMILES:
O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccc(cc1)C#N |r,wU:18.21,wD:15.17,(-2.12,.28,;-1.35,1.61,;.19,1.61,;.96,.28,;.33,-1.13,;1.48,-2.16,;1.48,-3.7,;2.81,-4.47,;4.14,-3.7,;5.61,-4.18,;6.51,-2.93,;5.61,-1.69,;4.14,-2.16,;2.81,-1.39,;2.49,.12,;3.58,1.2,;5.07,.81,;6.16,1.89,;5.76,3.38,;6.85,4.47,;8.33,4.07,;9.82,3.67,;4.27,3.78,;3.18,2.69,;-2.12,2.94,;-3.66,2.94,;-4.43,4.28,;-5.97,4.28,;-6.74,2.94,;-5.97,1.61,;-4.43,1.61,;-8.28,2.94,;-9.82,2.94,)|
Structure:
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