Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta [7-25]
Ligand
BDBM7782
Substrate
GSK-3 Peptide Substrate
Meas. Tech.
GSK-3 Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
7000±n/a nM
Citation
 Martinez, A; Alonso, M; Castro, A; Perez, C; Moreno, FJ First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem 45:1292-9 (2002) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta [7-25]
Synonyms:
G1T8E2_RABIT | GSK-3, beta | GSK3B | Glycogen Synthase Kinase-3, beta
Type:
Enzyme fragment
Mol. Mass.:
1972.14
Organism:
Oryctolagus cuniculus (rabbit)
Description:
Glycogen Synthase Kinase-3 is the beta isoform of the rabbit enzyme produced in E.coli.. Only partial sequence is available.
Residue:
19
Sequence:
TTSFAESCKPVQQPSAFGS
  
Inhibitor
Name:
BDBM7782
Synonyms:
4-Benzyl-2-ethyl-1,2,4-thiadiazolidine-3,5-dione | CHEMBL26241 | Thiadiazolidinone (TDZD) deriv. 9
Type:
Small organic molecule
Emp. Form.:
C11H12N2O2S
Mol. Mass.:
236.29
SMILES:
CCn1sc(=O)n(Cc2ccccc2)c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
GSK-3 Peptide Substrate
Synonyms:
GS-1 Peptide | Phospho-GS2 Substrate Peptide
Type:
Peptide
Mol. Mass.:
3045.17
Organism:
n/a
Description:
n/a
Residue:
27
Sequence:
YRRAAVPPSPSLSRHSSPHQSPEDEEE