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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM494524
Substrate
n/a
Meas. Tech.
Kinase Activity Inhibition Assay
IC50
<100±n/a nM
Citation
 Xue, B; Zheng, R; Cha, MY; Kim, M IRAK4 inhibitor and use thereof US Patent  US10988482 Publication Date 4/27/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM494524
Synonyms:
US10988482, Compound 28
Type:
Small organic molecule
Emp. Form.:
C20H27N7OS
Mol. Mass.:
413.54
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cnn(c2)C2CCCNC2)nc2ccsc12 |r,wU:1.0,wD:4.7,(-.41,-3.32,;.92,-2.55,;.92,-1.01,;2.26,-.24,;3.59,-1.01,;3.59,-2.55,;2.26,-3.32,;4.92,-.24,;4.92,1.3,;6.26,2.07,;6.26,3.61,;7.59,4.38,;7.59,5.92,;8.84,6.83,;8.36,8.29,;6.82,8.29,;6.35,6.83,;5.92,9.54,;6.54,10.95,;5.64,12.19,;4.11,12.03,;3.48,10.62,;4.38,9.38,;4.92,4.38,;3.59,3.61,;2.13,4.09,;1.22,2.84,;2.13,1.6,;3.59,2.07,)|
Structure:
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