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Target
Protein-lysine 6-oxidase
Ligand
BDBM50526721
Substrate
n/a
Meas. Tech.
LOX Activity in Cysts Assay
IC50
190±n/a nM
Citation
 Springer, C; Marais, R; Niculescu-Duvaz, D; Leung, L; Smithen, D; Callens, C; Tang, H Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer US Patent  US10995088 Publication Date 5/4/2021 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
LOX | LYOX_HUMAN | Lysyl oxidase | alpha-Glucosidase (alpha-Glu)
Type:
PROTEIN
Mol. Mass.:
46954.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306619
Residue:
417
Sequence:
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM50526721
Synonyms:
CHEMBL4444163 | US10807974, Example 111 | US10995088, Example 111 | US11608330, Example 111
Type:
Small organic molecule
Emp. Form.:
C16H18N4O2S2
Mol. Mass.:
362.47
SMILES:
CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Structure:
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