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Target
Dihydrofolate reductase
Ligand
BDBM50461741
Substrate
n/a
Meas. Tech.
TBD
IC50
1400±n/a nM
Citation
 Gangjee, A Pyrimidine compounds and pyrimido indole compounds and methods of use US Patent  US11001595 Publication Date 5/11/2021 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50461741
Synonyms:
CHEMBL4227112 | US11001595, Compound 6 | US11111252, Compound 6
Type:
Small organic molecule
Emp. Form.:
C15H17N5OS
Mol. Mass.:
315.393
SMILES:
COc1ccccc1Sc1c(C)c2c(N)nc(N)nc2n1C
Structure:
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