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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM500234
Substrate
n/a
Meas. Tech.
a time-resolved fluorescence resonance energy transfer (TR-FRET) assay
IC50
4.00±n/a nM
Citation
 Cai, S; Du, Z; Kim, M; Loyer-Drew, JA; Naduthambi, D; Patel, L; Phillips, BW; Phillips, G; Stevens, KL; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ; Yeung, SC Phosphatidylinositol 3-kinase inhibitors US Patent  US11021467 Publication Date 6/1/2021 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM500234
Synonyms:
US11021467, Compound 93
Type:
Small organic molecule
Emp. Form.:
C19H19ClN8O2
Mol. Mass.:
426.86
SMILES:
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1C[C@H](O)C1 |r,wU:25.27,27.30,wD:1.0,(2,1.38,;.67,.61,;.67,-.93,;2,-1.7,;3.33,-.93,;4.67,-1.7,;6,-.93,;4.67,-3.24,;3.33,-4.01,;3.33,-5.55,;2,-3.24,;.67,-4.01,;-.67,-4.78,;-.67,1.38,;-2,.61,;-3.33,1.38,;-4.67,.61,;-6,1.38,;-6,2.92,;-4.67,3.69,;-4.67,5.23,;-3.33,2.92,;-2,3.69,;-2,5.23,;-.67,2.92,;.67,3.69,;2.15,3.29,;2.55,4.78,;3.89,5.55,;1.07,5.18,)|
Structure:
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