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Target
Tyrosine-protein kinase SYK
Ligand
BDBM302012
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
IC50
0.911±n/a nM
Citation
 Altman, MD; Andresen, BM; Arrington, KL; Childers, KK; Di Francesco, ME; Ellis, JM; Haidle, AM; Liu, Y; Northrup, AB; O Boyle, B; Otte, RD; Reutershan, MH; Vitharana, D; Woo, HC Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors US Patent  US9598405 Publication Date 3/21/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM302012
Synonyms:
US9598405, 2.11
Type:
Small Organic Molecule
Emp. Form.:
C24H29N5O4S
Mol. Mass.:
483.583
SMILES:
Cc1cc(Nc2cc(OCCCN)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(5.83,2.98,;4.5,2.21,;3.17,2.98,;1.83,2.21,;.5,2.98,;.5,4.52,;1.83,5.29,;1.83,6.83,;3.17,7.6,;3.17,9.14,;4.5,9.91,;4.5,11.45,;5.83,12.22,;.5,7.6,;-.84,6.83,;-.84,5.29,;1.83,.67,;3.17,-.1,;4.5,.67,;3.17,-1.64,;4.41,-2.55,;3.94,-4.01,;2.4,-4.01,;1.92,-2.55,;1.49,-5.26,;2.87,-5.93,;1.07,-6.74,;-.43,-7.11,;-1.5,-6,;-1.07,-4.52,;.42,-4.15,;-2.99,-6.38,;-4.06,-5.27,;-3.42,-7.86,)|
Structure:
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