Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase SYK
Ligand
BDBM302018
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
IC50
0.092±n/a nM
Citation
 Altman, MD; Andresen, BM; Arrington, KL; Childers, KK; Di Francesco, ME; Ellis, JM; Haidle, AM; Liu, Y; Northrup, AB; O Boyle, B; Otte, RD; Reutershan, MH; Vitharana, D; Woo, HC Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors US Patent  US9598405 Publication Date 3/21/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM302018
Synonyms:
US9598405, 3.3 | US9598405, 3.7
Type:
Small Organic Molecule
Emp. Form.:
C23H23F3N4O3S
Mol. Mass.:
492.514
SMILES:
CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(ccn2)C(F)(F)F)n1
Structure:
Search PDB for entries with ligand similarity: