Reaction Details Report a problem with these data
Target
SH2B adapter protein 2
Ligand
BDBM479351
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
5.90±n/a nM
Citation
 Fu, J; Lou, Y; He, Y Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors US Patent  US11034705 Publication Date 6/15/2021 
Target
Name:
SH2B adapter protein 2
Synonyms:
APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN
Type:
Protein
Mol. Mass.:
67733.52
Organism:
Human
Description:
O14492
Residue:
632
Sequence:
MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEAAPGRARAVENQYSFY
  
Inhibitor
Name:
BDBM479351
Synonyms:
(3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5]decan- 8-yl)-6-(((6aS,8S)-8-(((methoxymethoxy)meth- oxy)methyl)-6a,7,8,9-tetrahydro-6H-pyrido[3,2- b]pyrrolo[1,2-d][1,4]oxazin-4-yl)thio)pyrazin- 2-yl)methanol | US10894797, Compound 40 | US11034705, Compound 40 | US11518772, Compound 40
Type:
Small organic molecule
Emp. Form.:
C28H40N6O6S
Mol. Mass.:
588.719
SMILES:
COCOCOC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1 |r|
Structure:
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